ALBEZIN

Active Ingredients:

Each tablet contains: Albendazole 360 mg; Zinc Oxide 100 mg.

Excipients:

Potato starch, polyvinylpyrrolidone, lactose, talc, magnesium stearate, aerosil, sodium croscarmellose.

Description:

White or nearly white tablet with a score line on one side and the inscription “BIO” on the other; white specks may be present.

Dosage Form:

• 50 tablets in a polyethylene bottle

• 15 tablets per blister, 6 blisters in a cardboard box

Pharmacotherapeutic Group:

Anthelmintic.
ATC vet code: QP52AC11

Target Species:

All types of animals and poultry.

Pharmacological Properties:

Albendazole, a benzimidazole carbamate derivative, exhibits broad-spectrum activity against adult and larval forms of nematodes, cestodes, and trematodes. It also has ovicidal activity, preventing contamination of pastures and stables.

Albendazole inhibits microtubule polymerization. Disruption of microtubules interferes with glucose uptake, leading to dysfunction of the microtubular system in helminths, causing their death and elimination from the body. Its efficacy is enhanced when administered with food.

Zinc has antiseptic, adsorptive, anti-inflammatory, astringent, and disinfectant effects. It plays a crucial role in metabolic processes, including protein and collagen synthesis, and promotes regeneration and epithelialization of tissues damaged by parasites in the gastrointestinal tract.

The combination of zinc and albendazole reduces potential side effects of albendazole (such as liver dysfunction, leukopenia, hypersensitivity reactions). These effects are mild.

According to its toxicological classification, Albezin tablets are considered low-risk substances (hazard class IV) and are well tolerated at the recommended dose.

Pharmacokinetics:

Albendazole is better absorbed orally than other benzimidazoles. About 47% of the dose is excreted in urine within 9 days as metabolites. Active metabolites (albendazole sulfoxide and sulfone) reach peak plasma concentrations within 20 hours.

Zinc is absorbed in the small intestine (duodenum and jejunum) via a specific protein synthesized by the pancreas. It is excreted mainly through feces and urine.

Indications:

Used for deworming of livestock, wild animals, and poultry against roundworms, lungworms, flatworms (tapeworms and flukes), and gastrointestinal invasions caused by immature and adult parasites. Effective against the following:

• Gastrointestinal helminths: Haemonchosis, bunostomosis, esophagostomiasis, nematodiriasis, ostertagiasis, cooperiosis, strongylosis, trichostrongylidosis, hyostrongylosis, parascaridosis, trichocephalosis, toxocarosis, toxascaridiosis, uncinariosis, ascariasis, heterakidosis.

• Lung helminths: Dictyocaulosis, protostrongylosis, Muelleriosis, neostrongylosis, cystocaulosis, metastrongylosis.

• Cestodiasis: Monieziasis, avitellinosis, thysanieziasis.

• Trematodiasis: Fascioliasis, dicrocoeliosis, paramphistomiasis.

Administration and Dosage:

Administer orally with feed, no fasting required. For fur animals and poultry, administer twice.

• Cattle, deer, camels, wild ruminants:

  • Nematodes: 1 tab/50 kg BW

  • Cestodes: 1 tab/35 kg BW

  • Trematodes: 1 tab/25–35 kg BW

• Sheep, goats:

  • Nematodes, cestodes: 1 tab/35–70 kg BW

  • Trematodes: 1 tab/45 kg BW

• Pigs: 1 tab/20–35 kg BW

• Horses, donkeys, mules: 1 tab/50 kg BW

• Fur-bearing animals, rabbits: 1 tab/7–10 kg BW

• Poultry:

  • Nematodes: 1 tab/25–30 kg BW

  • Lungworms: 1 tab/30–35 kg BW, once daily for 2 days

Side Effects:

No significant side effects observed even at triple the therapeutic dose.

Contraindications:

Hypersensitivity to components. Do not use in weakened animals, in acute fascioliasis, or in the first trimester of pregnancy.

Withdrawal Period:

• Meat: 14 days

• Milk: 3 days

Storage Conditions:

Store in a dry, dark place at temperatures up to 25°C.

Shelf Life: 2 years

Manufacturer:

Biotecsi LLC, 8 Yumashvili St., Tbilisi, Georgia